Diindolylmethane(DIM) is a natural chemical produced by the body when indole-3-carbinol, a molecule present in cruciferous vegetables such as broccoli, cauliflower, and kale, is broken down. Diindolylmethane, which is available as a supplement, is claimed to have a variety of health benefits.
DIM appears to have an effect on estrogen levels in your body, according to studies. As a result, DIM pills are becoming increasingly popular as a potential treatment for a wide range of hormone-related diseases, such as acne, hormonal problems, prostate difficulties, and certain types of cancer.
When you ingest cruciferous vegetables, the stomach acid degrades a component called indole-3-carbinol, resulting in a new chemical called DIM. Surprisingly, observational studies link a high consumption of cruciferous vegetables to a lower risk of some cancers, including breast and prostate cancer. While the precise process is uncertain, indole-3-carbinol is thought to play a role. \
Although cruciferous vegetables are the main source of DIM, you would need to consume multiple servings per day to receive the benefits of this component. As a result, consumers looking to cure a specific condition such as acne or prostate problems may seek a concentrated amount in the form of DIM supplements.
Mechanism of action
Although laboratory research reveal anti-inflammatory and anticancer benefits, human data is lacking.
A few clinical studies indicate that DIM may aid patients with castration-resistant prostate cancer or reverse aberrant cervical alterations in cells. More research is needed to determine the efficacy and safety of DIM, as it may modify the amounts of certain hormones in the body.
Diindolylmethane may operate like estrogen in the body, although there is indication that it may also prevent estrogen actions in certain conditions. Diindolylmethane also seems to aid in the destruction of cancer cells and the reduction of inflammation.
DIM supplements are being researched for their ability to protect against specific malignancies. They are also used to avoid prostate enlargement, treat acne, aid in weight loss, and alleviate premenstrual syndrome (PMS) and menopausal symptoms.
While these advantages appear to be promising, overall data on DIM’s efficacy and long-term safety in people is inadequate.
1.) May have anti-cancer properties.
DIM supplements may help limit the growth and spreading of breast cancer cells, according to test-tube and animal studies. Human research, on the other hand, are limited.
DIM might benefit individuals with castration-resistant prostate cancer and help reverse cervical intraepithelial neoplasia, according to preliminary research, but more research is needed.
Early findings from in vitro and animal studies suggest that diindolylmethane may provide modest protection against prostate cancer, ovarian cancer, and colon cancer. Nevertheless, due to a limited research, it is too early to determine whether diindolylmethane may aid in the treatment of certain types of cancer in humans.
According to preliminary studies, consuming diindolylmethane daily for 28 days may lower prostate-specific antigen (PSA) concentrations in men with prostate cancer. PSA levels can be used to track prostate cancer progression.
2.) May aid weight loss.
While diindolylmethane supplements are occasionally marketed as natural weight loss aid, there is no scientific evidence to support the idea that ingesting diindolylmethane improves weight reduction.
Given the importance of estrogen in regulating fat formation, DIM pills may aid in weight loss – however no human study currently supports this effect. DIM pills may also accelerate fat breakdown while inhibiting fat cell development. Remember that human studies are required.
3.) May fight acne.
Often DIM supplements have been used to cure hormonal acne. Nevertheless, no research currently validates this application.
4.) May alleviate PMS symptoms.
PMS symptoms are thought to be caused by fluctuations in estrogen levels on a monthly basis. Again, some people utilize DIM supplements to alleviate symptoms, but research has yet to demonstrate their efficacy.
Little is known regarding the long-term safety and adverse reactions of DIM supplements due to a shortage of human studies.
DIM supplements are not hazardous or have major negative effects, according to existing human studies.
The most common side effects include urine discoloration, increased bowel movements, headaches, and gas.
Adverse effects that are less common include nausea, vomiting, diarrhea, and skin rashes.
Precautions and warnings
Women who are pregnant, expecting to become pregnant, or breastfeeding should avoid using DIM due to the potential hormonal effects. Before using this product, women who use birth control tablets should discuss with a healthcare provider.
Because DIM supplements interfere with oestrogen levels, they may have an impact on those who have hormone-sensitive malignancies or are on hormone therapy. Such people should avoid DIM supplementation unless they are under the observation of a medical practitioner.
It is critical to consult your healthcare practitioner before using such supplements, regardless of your medical history.
Diindolylmethane(DIM) is a chemical that your body produces when you consume cruciferous vegetables. It’s also concentrated and available as a supplement. DIM, because it influences estrogen levels, may aid in the treatment of a number of illnesses, particularly hormone-sensitive cancers and prostate difficulties.
However, more research is needed, especially for usage linked to acne, weight loss, and PMS symptoms, which are not currently supported by human research. It would be too early to prescribe diindolylmethane supplements as a routine treatment for any health issue due to the lack of scientific foundation.
However, raising your diindolylmethane levels by eating indole-3-carbinol-rich cruciferous vegetables may assist in improving your overall health. Cruciferous vegetables are full of antioxidants, fiber, vitamins, and minerals, all of which promote good health. Regardless of DIM’s efficacy, eating more cruciferous vegetables is highly advisable.