A Biopsy is the removal of tissue from any part of the body, to examine for the disease. Some biopsies may be required to extract a small sample of tissue with a needle while others may be needed to extract a suspicious nodule or lump. The test can be used to evaluate samples of tissue from any part of the body to allow microscopic examination of the sample. Since most biopsies are minor procedures, patients usually do not need sedation. However, sometimes local anesthesia may be used.