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Risk Factors Involve in Carney Complex

Risk Factors Involve in Carney Complex

The symptoms and the severity of the carney complex vary from someone to another of someone who are among the same members of the family. The disorder can be obvious at birth, but the median age of the diagnosis is 20. Many of the signs and symptoms of Carney’s complexes are revealed between the year of adolescence or early early. It is important to keep in mind that affected individuals may not have any symptoms explained below. Parents of affected people and affected children should speak with their specific cases, relevant medical symptoms and medical equipment for the general prognosis.  The complex indication of Carney is often black or brown spots of a large number of small (strawberries) on the skin (multiple lentigines). These small and flat discolorations are similar, but tend to be dark and tend to be in the range of 2 to 10 millimeters. Lentidine is the most common eye of the eyelids, eyelid, eye and eye and genitals. Lentidine can be revealed during birth. In most cases, lentigines increase the number around adolescence.  Lentidine tends to be in the 40s. Other types of skin anomalies associated with the Carney complex are blue Nevi. Blue marine blue has aged, small, blue or bluish spots on the skin. The frequent individuals are affected to develop irregular or glazed pale brown discoloration regions with white spots due to the loss of pigment loss (hair loss lesion). 

 Individuals with Carney complexes tend to develop a type of tumor known as Mucusoma.  Mucus tumors are small benign tumors consisting of binding tissue. Myxomes can affect any area of the body, except hand and foot, and the Kearney complex is more commonly a heart (cardiac mucusioma). A mucusy or multiple mucus tumors may be present. Mucus tumors can develop any or all of the heart camera. A normal heart has four rooms. Two superior chambers known as atrial are separated from each other by fibrous partitions known as atrial septum. The two lower chambers are known as ventricles and are separated from each other by ventricular partition. The valve connects atria (left and right) to each ventricle. The valve allows to pump the blood through the camera. Blood moves to the lungs receiving oxygen through the pulmonary artery through the pulmonary artery. Blood returns to the heart through pulmonary vein and enters the left ventricle. The left ventricle sends the blood now oxycert to the main vein (aorta) of the body. 

 Cardiac mucusoma can generally potentially cause a potential processing of life to life for blood flow blockage. Specific complications of the blood pump pumping blood to the remaining part of a peeled cigeri or heart pumping blood, causing cardiac accumulation, lung and lung, and may include a stroke causing the accumulation of liquids in various ranges. Body fabric (congestive heart failure). The complete occlusion (blockade) of the valve opening can cause a sudden death.  Additional cardiac anomalies that can occur to people with Carney complexes include palpitations, diastolic bustling and “tumor plop”, which is a unique sound associated with the movement of the tumor in the heart. Cardiac mucusoma can also cause fatigue, fever, muscle pain (muscle pain), dyspnea (dyspnea) and non-specific general symptoms that include expected weight loss. 

 Frequently, instead of the heart or instead, Mucosa is observed in other areas of the body. These areas include nipples and auditory channels. It can affect any area of the body and other objects. Skin mpoma can be on white, pink or meat papules or small small nodules directly below the surface of the skin. In general, they do not cause symptoms and can not appear from birth until four years ago. In general, they are 1 cm or less in diameter. Mucusoma can also occur in the oral pharyngeal region, including tongue, hard palate and any wall and any wall (pharynx). In women, mucus tumors can also occur in the chest after adolescence.  In addition, women can develop mucusoma in a germ, including vagina, uterus and cervical cancer. In rare cases, affected individuals can develop a nasal muscle tumor, mainly a rare bone tumor that affects the long bone on the nasal nasal side or arms and legs. 

 People with Carney complexes can develop a wide variety of anomalies that affect endocrine systems, including the appearance of multi-franchise tumors. The endocrine system is a network of a gland that secretes hormones in the bloodstream, where it moves to several parts of the body. These hormones adjust the chemical process (metabolism) that affects the functions of various organs and activities in the body.  Hormones are involved in numerous vital processes in heart rate, body temperature and blood pressure, cell differentiation and growth and regulation of some metabolic processes. The most common endocrine tumor associated with the Carney complex is known as a disease of the main pigmental nodular cortex (PPNAD). PPNAD affects approximately 25 percent of people with Kerny complexes. This condition is characterized by a series of small nodules that affect the adrenal gland. The adrenal gland is found in the kidney and produces cortisol, which is a hormone involved in a particular metabolism and a cardiovascular process, and a body helps react to stress.  PPNAD is an unlikely disease with individuals with Carney complexes. The increase in cortisol levels for PPNAD can cause obstacles known as Cushing’s syndrome. 

Cushing’s syndrome is a disorder that occurs because of abnormally high levels of cortisol in the body. The symptoms develop slowly over time. Affected children may experience weight gain and growth delays. Adults may experience progressive weight gain resulting in extra fat in the midsection, between the shoulder blades, around the neck and in the face, giving the face a rounded appearance. Additional symptoms include high blood pressure (hypertension), fatigue, purple or red stretch marks (striae) on the abdomen, excessive thirst, weakness of the muscles closest to the body (proximal muscle weakness) and psychological disturbances. Some affected women may experience disturbances of their menstrual cycles and a male pattern of hair growth (hirsutism). Some affected individuals may have progressive thinning and loss of protein of bones (osteoporosis) because of prolonged mild elevation of cortisol.

Some individuals with Carney complex may have a benign tumor (adenoma) of the pituitary gland. The pituitary gland is a small gland located near the base of the skull that produces several hormones and releases them into the bloodstream as needed by the body. Infrequently, individuals with Carney complex can develop a condition known as acromegaly. Acromegaly occurs when a pituitary adenoma causes increased production of growth hormone. Symptoms include abnormal enlargement of the bones of the arms, legs and head. The bones in the jaws and in the front of the skull are typically most often affected. Consequently, affected individuals may exhibit abnormal enlargement of the hands, feet, jaws and face. Acromegaly may also cause thickening of the soft tissues of the body, particularly the heart and accelerated growth leading to tall stature. Acromegaly is a slowly progressive condition.

Some individuals with the Carney complex may have multiple tumors (nodules) affecting the thyroid. The thyroid is a butterfly-shaped gland at the base of the neck that secretes hormones that help to regulate growth and development in the body. In most cases, these nodules are benign non functioning adenomas. Nonfunctioning means that the adenoma does not produce excess hormones. Some affected individuals may have papillary or follicular thyroid carcinoma. In rare cases, thyroid carcinoma has developed in individuals with a longstanding history of multiple thyroid nodules.

In males, an endocrine tumor known as a large-cell calcifying Sertoli cell tumor (LCCSCT) may develop. This tumor is found in the testes as tiny areas of calcification and sometimes can be associated with early development of secondary sexual characteristics (precocious puberty). This tumor can potentially cause breast development in males (gynecomastia). LCCSCTs are almost always benign; only one case has ever been reported of malignant transformation. Approximately one-third of males with Carney complex have these tumors present when first diagnosed with the disorder, usually during the first decade of life. Virtually all adult males develop LCCSCTs at some point. Less frequently, two other testicular tumors can also occur in males with Carney complex, specifically Leydig cell tumors and pigmented nodular adrenocortical rest tumors. Leydig cell tumors potentially can become malignant. Pigmented nodular adrenocortical rest tumors are benign, but can cause Cushing’s syndrome.

In some cases, testicular tumors can affect fertility due to replacement and obstruction of the tiny tubes in which sperm is formed (seminiferous tubules) and decreased sperm motility (oligoasthenospermia). The presence of these tumors can cause the testes to become abnormally large (macroorchidism) as well.

Although not a frequent finding, some females with Carney complex have developed ovarian cysts. In approximately 10 percent of cases, individuals with Carney complex may develop a psammomatous melanotic schwannoma, which is a rare tumor of the peripheral nerve sheath. They can occur anywhere along the central and peripheral nervous system, but most often affect the gastrointestinal tract (including the esophagus) or the network of nerves adjacent to the spine (paraspinal sympathetic chain). Depending upon their location psammomatous melanotic schwannomas can cause pain or discomfort as well as damage to one or more nerves (radiculopathy). In rare cases, these tumors can become malignant.

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