Pomi-T

Pomi-T is a green tea, pomegranate seed extract, broccoli extract, and turmeric supplement capsule. Pomi-individual T’s components are high in polyphenols, natural plant-based phytochemicals linked to a lower risk of various chronic illnesses and anticancer properties. Pomi-T provides a wide range of polyphenols, each with its unique properties, by combining foods from various categories (fruit, vegetable, spice, and leaves).

Pomi-T is not a drug, so there are no specific dosage guidelines. The product is intended to be consumed as part of a healthy and well-balanced diet. The suggested daily dose is one capsule twice a day. Pomi-T is a straightforward way to maintain a consistent intake of various polyphenols.  Polyphenols and polyphenol supplements are the subjects of increasing scientific and clinical interest because of the possible health benefits associated with their consumption. Broccoli, turmeric, green tea, and pomegranate have been scientifically proven to help fight the most common cancer in men in the United States and the United Kingdom – prostate cancer(Pomegranate, Green Tea, Turmeric And Broccoli May Help Fight Prostate Cancer, n.d.).

Several extensive prospective cohort studies show that people who eat polyphenol-rich diets have a lower risk of cancer. The men were divided  into two groups:

  • The essence of pomegranate, turmeric, green tea and broccoli group
  • The placebo group
  • Every day, they took a capsule containing either the active ingredients (dubbed “Pomi-t”) or a placebo. After six months, the researchers discovered that those taking capsules containing pomegranate, turmeric, green tea, and broccoli essence had PSA levels that were 63 per cent lower than those in the placebo group.
  1. Pomegranate

Pomegranate fruit is a rounded berry with a thick reddish skin and 200–1400 white to deep red or purple seeds. Because of their high content of hydrolysable tannins and anthocyanins, pomegranate seeds are edible and have potent antioxidant and anti-inflammatory properties(Sharma et al., 2017). Pomegranate and its constituents have been shown in studies to effectively affect multiple signalling pathways involved in inflammation, cellular transformation, hyperproliferation, angiogenesis, tumorigenesis initiation, and finally, suppressing the final steps tumorigenesis and metastasis(Khan et al., 2008). Pomegranate has been used in various medical systems for the treatment and therapy of a wide range of diseases and ailments. The pomegranate was thought to be a whole pharmacy unto itself in the ancient Indian medicinal system, i.e., Ayurvedic medicine. With a high ellagic acid content, pomegranate has been proven to suppress cell proliferation directly and trigger aggressive human prostate cancer cells and apoptosis. A study involving oestrogen-sensitive and resistant breast cancer cell lines was found to block processes involved in cancer metastasis while enhancing cell adhesion and migration indicators in cancer but not normal cells. In another, it inhibited a chemokine that attracts breast cancer cells to the bone and the expression of a gene important in epithelial-to-mesenchymal transition. Pomegranate compounds may help slow the progression of breast cancer. It was discovered that pomegranates contain six compounds that appear to slow the progression of hormone-dependent breast cancer by inhibiting aromatase. This enzyme converts androgen to oestrogen. The researchers cautioned that their study was conducted in vitro and had not been tested on animals or humans.

2. Broccoli

Broccoli’s health benefits have also been extensively researched, mainly two components, sulforaphane and myrosinase: Broccoli, which contains isothiocyanate (ITC) and its metabolite sulforaphane, has been shown to inhibit cancer cell growth and promote apoptosis. According to one study, broccoli causes a slew of genetic changes, including the activation of cancer suppressor genes and the deactivation of promotion genes. Broccoli stimulates the antioxidant enzymes glutathione S-transferases, which explains why it is especially beneficial to the 50% of the population who has a mutated glutathione gene (GSTM1).

According to researchers from the University of Illinois at Urbana, broccoli’s enzyme myrosinase has potent anticancer properties. To maintain good myrosinase levels, broccoli should be lightly steamed. Sulforaphane, a component of broccoli, may prevent or treat breast cancer – re The Michigan Comprehensive Cancer Center gave cancer-infected mice varied quantities of sulforaphane derived from broccoli. They discovered that the number of cancer stem cells decreased significantly. They also found that the cancer cells were unable to form new tumours.

3. Turmeric

Curcumin, which gives turmeric its yellow colour, slows cancer cell growth by blocking the cell cycle, increasing the rate of apoptosis, and preventing cell invasion and migration. Turmeric was also found to help halt the growth of stem cells that give rise to breast cancer without harming normal breast cells in a study conducted at the University of Michigan2. Curcumin is a component of turmeric, a spice derived from the root rhizomes of a herbaceous perennial plant in the ginger family (Curcuma longa). Turmeric has been used medicinally for hundreds of years and is a common spice in Asian and Indian cuisines. Curcumin is said to have various health-promoting properties, including reducing inflammation, pain, and symptoms of metabolic syndromes. Curcumin is also said to have anti-cancer properties. Numerous studies suggest curcumin has anti-cancer properties, but the vast majority of these have been conducted in vitro. 2,3 These findings suggest that curcumin inhibits cell proliferation and induces cell cycle arrest, apoptosis, and senescence through various mechanisms in a variety of cancer cell lines. Curcumin has been shown to reduce the expression of numerous enzymes, transcription factors, inflammatory cytokines, growth factors, and other cell-signalling components involved in cancer growth and progression. Turmeric inhibits the growth of head and neck cancers. In a pilot study, Dr Marilene Wang and colleagues from UCLA’s Jonsson Comprehensive Cancer Center discovered that curcumin inhibits a cell signalling pathway that promotes the growth of head and neck cancers.“ The inhibition of the cell signalling pathway also correlated with reduced expression of several pro-inflammatory cytokines, or signalling molecules, in the saliva that promotes cancer growth,” said Dr Marilene Wang. This study found that curcumin can reduce cancer-promoting activities in the mouths of patients with head and neck cancer.

4. Green tea:

Green tea, high in epigallocatechin gallate (EGCG), inhibits ornithine decarboxylase, an enzyme that signals cells to increase faster and avoid apoptosis. Green tea has been shown in laboratory studies to significantly reduce several factors that promote breast and prostate cancer cell growth, angiogenesis and dedifferentiation, 

Anti cancer Mechanism

The most commonly mentioned anticancer mechanism of phytochemicals is via an antioxidant pathway, either by stimulating antioxidant enzymes such as the most frequently mentioned anticancer mechanism of phytochemicals is via an antioxidant path, either by producing antioxidant enzymes such as superoxide dismutase, catalase, and glutathione or by directly absorbing free radicals. The most commonly mentioned anticancer mechanism of phytochemicals is superoxide dismutase via an antioxidant pathway, either by stimulating antioxidant enzymes such as superoxide dismutase, catalase, and glutathione or by directly absorbing free radicals.attached test and glutathione or by directly absorbing free radicals. In either case, regular consumption shields DNA from oxidative damage caused by ingested or environmental carcinogens. An excellent example of this was shown in a laboratory study using cancer cell lines. They rapidly mutate into cancer cells when exposed to a known household carcinogen (triclocarban). Adding curcumin to the culture feed, on the other hand, significantly reduced the amount and rate of carcinogenesis. Another study from the University of Arkansas’ Food Safety Consortium discovered that marinating beef in rosemary and thyme reduced the level of heterocyclic amines (HCA) by 87%. In human and laboratory studies, this and other carcinogens produced by high-temperature grilling have been shown to increase the risk of prostate cancer. In addition to their ability to absorb antioxidants, certain phytochemicals can bind to the oestrogen receptor. These phytoestrogens compounds, primarily isoflavones and lignans, are found in soy products, legumes, pulses, and cruciferous vegetables and attach to the oestrogen receptor weakly without stimulating cell proliferation. At the same time, they prevent the binding of more dangerous oestrogens. This includes xenoestrogens and metaloestrogens, which are produced by own body and those that are ingested or absorbed. They have been shown to lower endogenous testosterone levels in men by inhibiting 5-alpha reductase.

Clinical Evidence

Pomi-T was examined in a short study of individuals with early-stage prostate cancer who were either active surveillance or waiting. Rising prostate-specific antigen (PSA) levels were monitored since they are a predictor of possible cancer activity. After six months, the PSA levels in the Pomi-T treatment group increased by 14.7%, whereas the levels in the non-Pomi-T group increased by 78.5%. The researchers determined that consuming Pomi-T had a significant short-term beneficial effect on PSA levels, significantly reducing the growth. (Understanding Prostate Changes – National Cancer Institute, n.d.) 

Pomi-T Components

The constituent ingredients in Pomi-T are all thought to be high in polyphenols, natural plant-based phytochemicals linked to a lower risk of a variety of chronic conditions as well as anticancer activities, as described. Background lab research, according to the Pomi-T official website, shows good benefits in a variety of cancer types. These effects are consistent with the impact of Pomi-separate T’s components (see right).

Anticancer effects in breast and prostate cancer cells, including reducing cancer growth factors and a slowdown of PSA doubling.

Cautions

Because Pomi-T omits the sugar found in pomegranate juice, it is generally safe to use in diabetics. Pomi-safety T’s in pregnancy has not been verified. Green tea, pomegranate seed extract, broccoli extract, and turmeric safety precautions should be followed.

Adverse Events/Side Effects

In the trial, Pomi-T was well tolerated, albeit a few adverse effects were seen when compared to control:

More flatulence and constipation

Mild indigestion that went away after Pomi-T was taken with meals

Drug Interaction

Pomegranate may interact with some medications, including warfarin, antihypertensives, and anticonvulsants. Although not proven in humans, high dosages of polyphenols have been shown in lab tests to have antioxidant effects that may limit the effectiveness of chemotherapy. According to the Pomi-T website, it is advisable to avoid taking Pomi-T one day before and three days after chemotherapy administration until this issue is rectified. One or more of the components in Pomi-T may cause hypersensitivity in some people. It is not recommended for persons who are allergic to pomegranate or caffeine.

Conclusion

Polyphenol-rich foods including pomegranate, green tea, broccoli, and turmeric exhibit anti-neoplastic effects in cell lines and animal models, including anti-angiogenesis, pro-apoptosis, and decreased proliferation. Some have been studied in tiny phase II trials.

This study discovered a statistically significant, beneficial effect on the percentage rise in PSA in this group of individuals with prostate cancer. Future studies will look at the long-term clinical harms and benefits of ADT for men.