Melatonin, known as N acetyl-5-methoxytryptamine is a multitasking hormone produced by the pineal gland and other organs of the body such as bone marrow, retina, and skin. The secretion of Melatonin is regulated by the master biological clock of the hypothalamus, in the human brain. It plays a vital role in Cancer Treatment through different applications and may have therapeutic significance.

Epidemiological applications have indicated a primary oncostatic property of Melatonin on different types of cancers. The underlying reasons Melatonin is an active cancer-fighting agent are its antioxidant property, modulation by Melatonin receptors, stimulation of apoptosis, regulation of tumor metabolism, inhibition of metastasis, and induction of epigenetic alteration.

Research shows that Melatonin induces a significant decrease in tumor size and promotes immunity against carcinogenic compounds. The Melatonin hormone is involved in redox processes of the cells, enhancing the augmentation of Natural Killer Cell activity and protects receptors from the toxic side effects of Chemotherapy and Radiotherapy. It can also be an excellent candidate for preventing and treating several types of cancer, such as gastric cancer, prostate cancer, breast cancer, and Colorectal Cancer.