Global incidences of Hodgkin’s Lymphoma
The incidence of Hodgkin’s lymphoma is 2-3 cases per 100,000 individuals per year. Often a peak in the disease rate can be observed in the third decade of life; however, a second peak in the age group over 60 years is also observed1. Hodgkin’s lymphoma (HL) affects approximately 8,480 new individuals in the United States each year2.
About 56% of patients diagnosed with HL in 2017 are expected to be males3. The mean age of diagnosis for the disease is 39 years. HL is most common in the age group of 20-34 years, accounting for about a third of new diagnoses. Although the incidence does not appear to be different between white and black Americans (3.1 new cases per 100,000 men), it is about half that of the Asia-Pacific population (1.6 new cases per 100,000 men) and Native American/Alaskan populations. The incidence is also lower in Hispanic Americans (2.6 new cases per 100,000 men) than in the white/black population. Although the incidence of HL has remained stable since the mid-1970s, the mortality rate has steadily declined from 1.3 individuals per 100,000 in 1975 to 0.3 individuals per 100,000 in 2014. The relative 5-year survival rate of HL patients at all stages of diagnosis improved from 70% to 85% over the same period4.
Incidences of Hodgkin’s Lymphoma in India
Hodgkin’s lymphoma is also very common in India. Data from some cancer hospitals in the Indian subcontinent suggest that HL’s demographic profile and response to treatment differ from the West5,6. In a study by Saito et al., Mumbai in India was found to have high incidences of Hodgkin lymphoma (19.0% and 17.1% in males and females, respectively) despite the overall low incidence rate of malignant lymphoma7.
- 1.Momotow J, Borchmann S, Eichenauer D, Engert A, Sasse S. Hodgkin Lymphoma-Review on Pathogenesis, Diagnosis, Current and Future Treatment Approaches for Adult Patients. J Clin Med. 2021;10(5). doi:10.3390/jcm10051125
- 2.Siegel R, Miller K, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7-30. doi:10.3322/caac.21590
- 3.Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA: A Cancer Journal for Clinicians. Published online January 2018:7-30. doi:10.3322/caac.21442
- 4.Time CS. SEER cancer statistics review 1975-2008. National Cancer Institute. Published 2011. Accessed March 2022. https://seer.cancer.gov/archive/csr/1975_2008/
- 5.Jain S, Lone M, Goswami A, et al. Lymphoma subtypes in India: a tertiary care center review. Clin Exp Med. 2021;21(2):315-321. doi:10.1007/s10238-021-00683-2
- 6.Shanmugasundaram S, Balan K, Arumugam D. Immunohistochemical profile and distribution of Non-Hodgkin and Hodgkin lymphoma – An experience in a medical college hospital in Tamil Nadu. Indian Journal of Medical and Paediatric Oncology. Published online September 2020:695-701. doi:10.4103/ijmpo.ijmpo_90_20
- 7.Saito E, Matsuoka J. International comparison of Hodgkin and non-Hodgkin lymphoma incidence. Japanese Journal of Clinical Oncology. Published online December 23, 2019:96-97. doi:10.1093/jjco/hyz202