Sunday, June 26, 2022
HomeCancer BlogsGrape seed extracts modify the outcome of oxaliplatin in colon cancer cells...

Grape seed extracts modify the outcome of oxaliplatin in colon cancer cells by interfering with cellular mechanisms of drug cytotoxicity

Grape seed extracts modify the outcome of oxaliplatin in colon cancer cells by interfering with cellular mechanisms of drug cytotoxicity

Colorectal cancer or colon cancer is the third most common cancer in both men and women, accounting for 9% of all cancer deaths from all organs. Colorectal cancer is preventable because healthy lifestyle changes, especially dietary habits, can help reduce the risk of this malignant disease.

There are ways to fight this type of cancer without the harsh or toxic chemicals used in chemotherapy. With the advent of new methods, we have been looking for natural ways to treat and fight cancer. One of those keys may be the right dose of grape seed to prevent colon cancer. So, we will see the efficacy of grape seed extract for colon cancer treatment.

Nature has tons of chemopreventive and anticancer agents. Many fruits and vegetables contain some type of chemopreventive agent. When it comes to grape seed extract (GSE), it’s packed with antioxidants. Consumer interest has peaked due to the fact that the antioxidants present in grape seeds are superior to both vitamin C and vitamin E. Besides that, the reason why they need grape seed extract is for prevention The increased anti-cancer effects may be due to the high antioxidant content. in the form of proanthocyanidins.

What is grape seed extract?

The grape seed extract is plant-based and derived from the dried and crushed seeds of grapes. Its medicinal nature has been known for a very long time and has been used in various cultures to treat various ailments and diseases. It is known to be a rich source of proanthocyanidin which is an antioxidant superior to even vitamin C and vitamin E. Because of this, grape seed extract has emerged as a highly dietary supplement today for treating and preventing cancer and also for other tons of health benefits.

GSE and modification of outcome of oxaliplatin

GSE might have been established as an excellent chemopreventive and anti-cancer dietary supplement. However, the question of whether these natural extracts interfere with the chemotherapeutic agents used in the treatment of colon cancer remains unresolved. The cytotoxicity of Italian and Palieri plant extracts alone or in combination with oxaliplatin was evaluated on colon cancer cells. Grape seed extracts exhibiting concentration-dependent antiproliferative activity are used to stimulate apoptosis. Combined, they affect Erk1/2 activation and antagonise the intrinsic and extrinsic pathways of oxaliplatin-induced apoptosis, DNA damage, and ROS generation. 

Prominent grape seed extracts strongly enhanced the absorption of oxaliplatin into all cells, by affecting the cellular platinum transport system. The addition of these natural extracts to oxaliplatin significantly reduced the cellular response to oxaliplatin and allowed a very large accumulation of platinum in the cell. Here, we elucidate the underlying chemical biology of the combination of grape seed extract and oxaliplatin, demonstrating that they may interfere with the efficacy of oxaliplatin in the treatment of colon cancer.

Should I choose grape seed extract for cancer? 

Even though grape seed might interfere with chemotherapy, there are tons of reasons to try it. When we talk about cancer, one of the challenges is whether the patient is able to recover after being treated for the disease. Chemotherapy and other cancer drugs are very good at killing cancer cells, but they are not capable of killing cancer stem cells. So if the cancer stem cells come back, they can be very difficult to treat. Because they are left behind and when the medicine is gone they grow back very quickly and the disease recurs. 

Studies have shown that grape seed extract not only kills colon cancer cells but also attacks cancer stem cells. Now, if you can target cancer stem cells, you can reduce the risk of cancer coming back, which in turn increases the chance of a cure, or at least you can slow the progression of the disease. 

How can GSE be taken? 

Not just colon cancer, GSE has shown to be effective against a whole bunch of numerous cancers like colon, breast, skin, and lung cancer. Its cancer-preventive properties are not hidden from the world now. It is slowly becoming a popular dietary supplement choice for cancer patients and all others who want to boost their health.

You can incorporate this remarkable chemopreventive agent into your lifestyle to reduce the risk of so many cancers. It comes in all sorts of concentrations and forms to give you the benefits of GSE. You can choose the liquid form or take it as an oral pill or capsule. 

When should I avoid the GSE?

If you are taking warfarin or other anticoagulants, you should avoid taking GSE. According to laboratory studies, grape seeds can increase the risk of bleeding. The clinical relevance has not yet been determined. If you are taking the CYP3A4 substrate and/or UGT substrate. Laboratory studies suggest that grape seeds may increase the risk of side effects. However, the clinical relevance has not yet been determined. 

Side effects and risks 

All medicines have some side effects. GSE is no exception. The grape seed extract is generally considered safe. Headache, itching of the scalp, dizziness, and nausea are some of the side effects of using GSE. 

If you are asking about the risks associated with GSE, do not use grape seed extract if you are allergic to grapes. Another caveat is that if you have a bleeding disorder or high blood pressure, consult your doctor before you start using grape seed extract. People taking medicines should consult their doctor before starting to use grape seed extract. GSE may interact with drugs such as anticoagulants, NSAID analgesics (aspirin, Advil, alive, etc.), certain heart medications, and cancer treatments.

Summing up

We have discussed a relatively unaddressed topic about GSE. Whether GSE really messes up with the chemotherapy or not, it is something that can be clearly understood in subsequent topics. But this doesn’t mean you should stay away from GSE and its benefits. You can still incorporate this into your life as a chemo preventive.

LEAVE A REPLY

Please enter your comment!
Please enter your name here