Latest Research on Esophageal Cancer

Executive Summary

Several research studies have been conducted to seek more information on esophageal cancer, related prevention methods, diagnostic process at the initial phase, and best treatments strategies. Research on esophageal cancer implicates the ongoing clinical trials and appropriate doctor communication with the patients and their families, providing effective treatment. Researchers are looking at using aspirin and acid-reducing medication to prevent oesophagal adenocarcinoma in people with Barrett’s oesophagus for chemoprevention. Researchers are studying PET scans to evaluate and possibly change the treatment before surgery. Research is going to find new drugs that are effective for esophageal cancer. Several targeted therapies are currently being studied for esophageal cancer. Researchers look at new drugs that block vascular endothelial growth factors (VEGF). Clinical trials are going on to find more acceptable ways of lessening symptoms and side effects of current cancer treatments to improve comfort and quality of life during treatment.

Advancement in Esophageal Cancer Research

Doctors are learning more about esophageal cancer, ways to prevent it, the best way to treat it, and how to give the best care to people diagnosed with this disease. The following research areas may comprise new alternatives for patients with the help of clinical trials. Always talk with the doctor about the best diagnostic and treatment options for you.

• Chemoprevention – Researchers are looking at using aspirin and acid-reducing medication to prevent esophageal adenocarcinoma in people with Barrett’s esophagus ^​1​. Research is still ongoing, and people are encouraged to talk with their doctor before taking any medications or dietary supplements for this reason.
• Use of PET scan – In addition to helping find out cancer’s stage, PET scans may be used to determine how well treatment is working to shrink a tumor before surgery. Researchers are studying PET scans to evaluate and possibly change the treatment before surgery ^​2​.
• Chemotherapy advances – Doctors are studying combinations of different drugs, such as cisplatin (available as a generic drug), capecitabine (Xeloda), docetaxel (Docefrez, Taxotere), Efudex), irinotecan (Camptosar), fluorouracil (5-FU, oxaliplatin (Eloxatin), paclitaxel, and trifluridine-tipiracil combination (Lonsurf). Research is going to find new drugs that are effective for esophageal cancer ^​3​.
• Targeted therapy – Several targeted therapies are currently being studied for esophageal cancer. For example, researchers look at new drugs that block vascular endothelial growth factors (VEGF) ^​4​.
• Immunotherapy – New drugs and combinations that include immunotherapy continue to be studied ^​5​.

Palliative care/supportive care – Clinical trials are going on to find more acceptable ways of lessening symptoms and side effects of current cancer treatments to improve comfort and quality of life during treatment.

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