Dimethylglycine (DMG) (also known as N,N-dimethylglycine) is a  derivative of the amino acid glycine .it is an amino acid that occurs naturally in plant and animal cells, as well as in a variety of foods such beans, cereal grains, and liver. It’s used to strengthen the immune system, improve vitality, and treat seizures and autism. DMG’s immune system effectiveness has been reported to be favorable. None of these claims, however, have been proven in clinical research. When one of the methyl groups in trimethyl-glycine is lost, it can be produced. It is also a byproduct of choline metabolism. Dimethylglycine has been proposed as an anti-inflammatory, immuno-stimulant, and therapy for autism, epilepsy, and mitochondrial illness.
DMG was once known as Vitamin B16, however unlike real B vitamins, a shortage of DMG in the diet has no negative consequences, and it is produced by the human body in the citric acid (or Krebs) cycle, thus it does not satisfy the criteria of a vitamin.

Dimethylglycine | Memorial Sloan Kettering Cancer Center

DMG is generated in cells as a byproduct of choline metabolism and is regarded as an antioxidant and oxygen enhancer at the cellular level. Choline and DMG levels are greater in foetal plasma than in maternal plasma. DMG levels in the blood have been shown to be lower in cystic fibrosis patients than in healthy youngsters.

It is only present in trace levels in the body and only for a few seconds at a time.
Attention deficit hyperactivity disorder (ADHD), epilepsy, chronic fatigue syndrome (CFS), allergies, respiratory diseases, pain and swelling (inflammation), cancer, alcoholism, and drug addiction are all conditions treated with dimethylglycine. It’s also utilized to help with autistic speech and behaviours, nervous system function, liver function, oxygen utilization, and sports performance. It is used by some individuals to relieve stress and the affects of ageing, as well as to strengthen the immune system’s defenses against infection.

DMG was utilized as an ester to improve the solubility and bioavailability of a cancer research prodrug , on the other hand, is not the active moiety, and there is no evidence that it possesses anticancer properties.

Dimethylglycine has been used to boost immunological function and treat autism and seizures, however the evidence is inconsistent or nonexistent.

It’s used to strengthen the immune system, improve vitality, and treat seizures and autism. DMG’s immune system effectiveness has been reported to be favorable. None of these claims, however, have been proven in clinical research.

DMG has no possible side effects if used for a short period of time, although more study is needed.

Dimethylglycine (DMG) is an amino acid derivative that has been studied for its potential role in cancer treatment and prevention. While there is some research suggesting that DMG may have anti-cancer properties, the available evidence is limited and inconclusive.

DMG is known to have several biological functions, including acting as a methyl donor in various metabolic pathways. It has been suggested that DMG might support immune function, enhance cellular energy production, and modulate gene expression, which could potentially have implications for cancer treatment.

In terms of its anti-cancer effects, some studies have shown that DMG can inhibit the growth of cancer cells in vitro (in a laboratory setting). For example, a study published in the journal “Cancer Letters” in 2007 reported that DMG inhibited the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis (programmed cell death). Another study published in “Oncology Reports” in 2017 found that DMG suppressed the growth and migration of liver cancer cells.

In addition to its direct effects on cancer cells, DMG may also have immunomodulatory properties that could be beneficial in cancer treatment. A study published in “Medical Science Monitor” in 2017 investigated the effects of DMG on immune function in patients with advanced cancer. The researchers found that DMG supplementation improved immune parameters and enhanced the effectiveness of chemotherapy in these patients.

Despite these promising findings, it’s important to note that most of the research on DMG and cancer has been conducted in vitro or in animal models. Clinical studies involving human subjects are limited, and there is a lack of well-designed randomized controlled trials to evaluate the efficacy and safety of DMG specifically for cancer treatment.

Furthermore, the mechanism of action by which DMG exerts its potential anti-cancer effects is not fully understood. More research is needed to elucidate the underlying mechanisms and to determine the optimal dosage, treatment duration, and potential side effects of DMG in the context of cancer treatment.

It’s worth mentioning that DMG is sometimes used as a supplement for general health and well-being, and it is available over the counter. However, if you’re considering using DMG or any other supplement as part of your cancer treatment, it’s crucial to consult with your healthcare provider first. They can provide personalized advice based on your specific situation and guide you in making informed decisions about your treatment options.

In summary, while there are some promising findings suggesting that DMG may have anti-cancer properties, the available research is limited and inconclusive. Further studies, particularly well-designed clinical trials, are needed to determine the potential benefits and risks of DMG as a therapeutic option for cancer.