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Daratumumab and Hyaluronidase-Fihj to Treat Multiple Myeloma


Daratumumab and hyaluronidase-fihj may be a sort of daratumumab that’s given as an injection. This form is often given in less time than daratumumab, which is given as an infusion. Daratumumab and hyaluronidase-fihj injection is employed with other medications to treat myeloma (a sort of cancer of the bone marrow) in newly diagnosed adults who are unable to receive certain other treatments. Daratumumab and hyaluronidase-fihj injection is additionally utilized in combination with other medications to treat myeloma in adults that have returned or haven’t improved after other treatment(s). This is also used to treat adults with multiple myeloma who have received at least three lines of treatment with other medications and were not treated successfully. Daratumumab is called monoclonal antibodies during a class of medication. It helps the body to slow or stop the expansion of cancer cells. Hyaluronidase-fihj is an endoglycosidase. It helps to stay daratumumab longer within the body so that the medication will have a greater effect.

Daratumumab and hyaluronidase-fihj injection come as an answer (liquid) to be injected subcutaneously (just under the skin) into the abdomen (stomach) over 3 to 5 minutes. How long the treatment will be continued depends on the length of treatment and how the body responds to it.

A doctor or nurse will watch you closely while you are receiving the medication and afterwards to be sure you are not having a serious reaction to the medication. You will tend other medications to assist prevent and treat reactions to daratumumab and hyaluronidase-fihj before and after you receive your medication. Tell your doctor or nurse immediately if you experience any of the subsequent symptoms: difficulty breathing or shortness of breath, pain, wheezing, throat tightness and irritation, cough, runny or stuffy nose, headache, itching, nausea, vomiting, fever, chills, rash, hives, or dizziness or lightheadedness. In case of any reaction, your doctor may temporarily or permanently stop your treatment. This depends on how well the medication works for you and therefore the side effects you experience. Be sure to tell your doctor how you are feeling during your treatment with daratumumab and hyaluronidase-fihj.

Side effects:

  • Constipation
  • Diarrhoea
  • Vomiting
  • Nausea
  • Stomach pain
  • Loss of appetite
  • Fatigue
  • difficulty falling asleep or staying asleep
  • Pain, burning or tingling within the hands or feet
  • Swelling of the hands, ankles, or feet
  • Back pain
  • Itching, swelling, bruising, or redness of the skin at the injection site

Some side effects can be serious. If you experience any of those symptoms, call your doctor immediately or get emergency medical treatment:

  • Unusual bruising or bleeding
  • Pale skin, fatigue, or shortness of breath
  • Yellow eyes or skin; dark urine; or pain or discomfort in the right upper stomach area


  • Tell your doctor and pharmacist if you’re allergic to daratumumab, hyaluronidase-fihj, the other medications, or any of the ingredients in daratumumab and hyaluronidase-fihj injection. Ask your pharmacist for an inventory of the ingredients.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you’re taking or decide to take.
  • Tell your doctor if you’re pregnant, planning conceiving, or are breastfeeding. You should use contraception to stop pregnancy during your treatment with daratumumab and hyaluronidase-fihj and for a minimum of 3 months after your final dose.
  • If you’re having surgery, including dentistry, tell the doctor or dentist that you simply are receiving daratumumab and hyaluronidase-fihj injection.


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