Executive Summary
Several latest research studies help to get more information on childhood germ cell tumor, related prevention methods, diagnostic process at the initial phase, and best treatment strategies. Additionally, clinical trials are researching new chemotherapy combinations to treat extracranial, extragonadal germ cell tumors. A clinical trial called the TIGER trial is investigated using high-dose chemotherapy instead of the standard dose offered for germ cell tumors, especially for testicular tumors that have returned. Researchers are looking for new ways to classify tumors. Hence, it will help doctors to identify those patients who have a high risk of tumor returning after treatment. Clinical trials are underway to find better ways to reduce symptoms and side effects of the presently available eye cancer treatments. Thus, it will help improve patients’ comfort and quality of life.
Advancement in Childhood Germ Cell Tumor Research
Doctors are learning about eyelid cancer, methods to prevent it. Thus it will help provide the best care to patients diagnosed with this cancer.
The following research areas may include new options for patients through clinical trials. Hence, always talk to the doctor about the diagnostic and treatment options best for you.
- Combination chemotherapy – Clinical trials are on to research new chemotherapy combinations to treat extracranial, extragonadal germ cell tumors 1.
- High-dose therapy – A clinical trial called the TIGER trial is researched using high-dose chemotherapy instead of the standard dose offered for germ cell tumors, especially for testicular tumors that have returned 2.
- A new method for classifying germ cell tumors
- Research is on classify tumors so that doctors can better identify those patients who have a high risk of tumor returning after treatment 3. This evidence points to a new form of classification for high-risk tumors. Basically, this is similar to the process of identifying adult germ cell cancer.
Palliative care/supportive care
Clinical trials are underway to find ways to reduce symptoms and side effects of available germ cell tumor treatments. Thus, it will help improve patients’ comfort and quality of life.
References
- 1.Shah R, Xia C, Krailo M, et al. Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? Gynecologic Oncology. Published online August 2018:253-260. doi:10.1016/j.ygyno.2018.05.025
- 2.McHugh DJ, Feldman DR. Conventional-Dose versus High-Dose Chemotherapy for Relapsed Germ Cell Tumors. Advances in Urology. Published online 2018:1-7. doi:10.1155/2018/7272541
- 3.Frazier AL, Hale JP, Rodriguez-Galindo C, et al. Revised Risk Classification for Pediatric Extracranial Germ Cell Tumors Based on 25 Years of Clinical Trial Data From the United Kingdom and United States. JCO. Published online January 10, 2015:195-201. doi:10.1200/jco.2014.58.3369