Clinical Trials about Childhood Acute Lymphoblastic Leukemia

Executive Summary

Clinical trials are considered a better method for treating childhood acute lymphoblastic leukemia. The evaluation of new drugs, different combinations of treatments, new approaches to surgery, and new therapies are also a part of the clinical trials of childhood acute lymphoblastic leukemia. Volunteers or patients willing to participate in the clinical trials should communicate with their doctor and healthcare team and research expertise to make well-decided informed choices regarding participation while signing informed consent. Clinical trials also focus on deriving methods to manage and relieve the side effects of cancer treatments. The volunteers willingly participate as they know the studies are a way to help advance the treatment of childhood acute lymphoblastic leukemia. Eligibility criteria for childhood acute lymphoblastic leukemia clinical trials ensure that the participants are safe, bound to no ill effects, and well-structured research.

Clinical Trials of Childhood Acute Lymphoblastic Leukemia

On the path to finding different ways to treat cancer, various research and trials are underway to discover safe and effective treatments other than the standard ones. Every drug that is used now was once tested in clinical trials. The clinical studies mainly focus on finding a safe, effective, and better treatment or diagnostic procedure ​1​. They evaluate new chemotherapy or radiotherapy drugs for better treatment of cancer.

Taking part in clinical trials can benefit people by receiving treatment before it is available. As every coin has two sides, there are some risks with the clinical trials, including its side effects and the possibility of new clinical trials not working. Clinical trials also experiment with the various drugs and other therapies that can relieve the symptoms and side effects of treatments like chemotherapy, radiotherapy, etc. Therefore, patients are strongly encouraged to talk with their health care team about the pros and cons of joining a specific study.

Reasons for Participation

Participating in clinical trials can have many reasons. For some people, taking part in a clinical trial is the only option to receive the best treatment for the type of cancer ​2​. Because standard treatments are not perfect, people are willing to face the uncertainty and challenges of a clinical trial to seek a better result. 

Some clinical trials study new ways to relieve symptoms and side effects during treatment. Others learn ways to manage the late effects that may happen a long time after treatment. Insurance and the costs of clinical trials change depending upon location and study. Some of the expenses from participating in the clinical trial are reimbursed in several programs. Clinical trials also have specific “eligibility criteria” rules that help research patients be safe. You and your research team carefully review these criteria together. People participating in a clinical trial can also stop participating at any time for any medical or personal reasons. The reasons may include that the new treatment is not working or has severe side effects. Experts keep an eye on clinical trials for any problems with each study.


  1. 1.
    Kotecha RS, Gottardo NG, Kees UR, Cole CH. The evolution of clinical trials for infant acute lymphoblastic leukemia. Blood Cancer Journal. Published online April 2014:e200-e200. doi:10.1038/bcj.2014.17
  2. 2.
    Pui CH, Mullighan CG, Evans WE, Relling MV. Pediatric acute lymphoblastic leukemia: where are we going and how do we get there? Blood. Published online August 9, 2012:1165-1174. doi:10.1182/blood-2012-05-378943