Trifluridine and Tipiracil Hydrochloride

US Brand Name(s): Lonsurf

Use of Trifluridine and Tipiracil Hydrochloride in Cancer Treatment

Experts have authorized Trifluridine and tipiracil hydrochloride to treat the following conditions:

Colorectal cancer has spread to other regions of the body (spread to other parts of the body). Doctors utilize it in people who’ve had fluoropyrimidine, oxaliplatin, irinotecan hydrochloride, and a VEGF inhibitor before. Patients with cancers that contain the wild-type KRAS gene should have been given an EGFR inhibitor as well.

Adenocarcinoma of the stomach or gastroesophageal junction adenocarcinoma (a rare form of esophageal cancer) that has spread to other parts of the body. Doctors utilize it in people who’ve had at least two fluoropyrimidine and platinum chemotherapy treatments, as well as either a taxane or irinotecan. However, they may use HER2/neu-targeted treatment in some instances.

Other kinds of cancer are being researched using trifluridine and tipiracil hydrochloride.

Detailed scientific definition- Definition from the NCI Drug Dictionary 

Trifluridine and Tipiracil Hydrochloride Information from MedlinePlus – A summary of key facts regarding this medication in layman’s terms, which may contain the following:

Cautions about this medicine; what are its uses and how to use it; what you should tell your doctor before taking it; things you should know about it before using it; other drugs that might interact with it; and possible negative effects.

Experts frequently investigate drugs to see whether they can treat or prevent conditions other than those with authorization. This patient information leaflet only covers authorized uses of the medications. However, much of the material might also apply to authorized uses under investigation.