US Brand Name(s) for Topotecan hydrochloride: Hycamtin
Use in Cancer Treatment
Experts have authorized Topotecan hydrochloride for usage alone or in combination with other medications to treat the following conditions:
Cervical cancer that has spread to other organs, has recurred (returned), or cannot be treated with other treatments. Experts use it in conjunction with cisplatin.
Ovarian cancer has spread to other organs. Experts use it on its own in people whose cancer has worsened as a result of conventional treatments.
Platinum-sensitive small cell lung carcinoma is a kind of lung cancer. Experts use it on its own in patients whose cancer has progressed following first-line chemotherapy.
Topotecan hydrochloride is also being researched for use in the treatment of various cancers.

For a detailed definition and related information Definition from the NCI Drug Dictionary
Topotecan Hydrochloride – Topotecan Hydrochloride – Topotecan Hydrochloride – Topotecan Hydrochlor A summary of key facts regarding this medication in layman’s terms, which may contain the following:
Cautions about this medicine; what are its uses and how to use it; what you should tell your doctor before taking it; things you should know about it before using it; other drugs that might interact with it; and possible negative effects.
Experts frequently investigate drugs to see whether they can treat or prevent conditions other than those with authorization. This patient information leaflet only covers authorized uses of the medications. However, much of the material might also apply to authorized uses under investigation.