Use in Cancer Treatment

Selpercatinib is to treat the following conditions:

  • Thyroid cancer that is progressed or metastatic and contains a specific mutation in the RET gene. It is also for adults and adolescents aged 12 and up who require systemic treatment. 
  • A metastatic non-small cell lung carcinoma with a RET fusion gene. Adults are the ones who utilize it. 
  • Thyroid carcinoma with a RET fusion gene that has spread or progressed. It is also for adults and children aged 12 and above who require systemic therapy, as well as those who have previously received radioactive iodine and found that it was ineffective or no longer effective. 

The FDA’s Accelerated Approval Program has authorized this usage. Confirmatory trials are necessary as a condition of approval.

Selpercatinib is also under research for use in the treatment of other cancers.

Definition from the NCI Drug Dictionary – Detailed scientific definition

Selpercatinib -Facts on MedlinePlus

A summary of key information regarding this medication in layman’s terms, which may contain the following:

  • Cautions about this medicine
  • What is the use and how?
  • Whom should you consult before taking it?
  • What you should know about it before using it?
  • Other drugs that might interact with it
  • Possible negative effects

Drugs are frequently under research to see whether they can assist treat or prevent conditions other than those already prevalent. This patient information leaflet covers uses which have been under authorization. Much of the material, though, might also apply to authorized uses that are being investigated.