Folfiri (chemotherapy)


A chemotherapy regimen consisting of leucovorin calcium (calcium folinate), 5-fluorouracil, and irinotecan exists within the treatment of advanced-stage and metastatic colorectal cancer. Degarelix, sold under the name Firmagon among others, maybe a hormonal therapy utilized in the treatment of prostatic adenocarcinoma.

FOL = Leucovorin Calcium (Folinic acid)

F = fluorouracil 

IRI = Irinotecan Hydrochloride


Leucovorin injection exists to stop the harmful effects of methotrexate (Rheumatrex, Trexall cancer chemotherapy medication) when methotrexate treats certain sorts of cancer. It treats people that have accidentally received an overdose of methotrexate or similar medications. Leucovorin injection is also treats anaemia (low level of red blood cells) which are aresult of low levels of folic acid in the body. Experts additionally use it with 5-fluorouracil (a chemotherapy medication) to treat colorectal cancer (cancer that begins within the large intestine). Leucovorin injection is during a class of medicines called vitamin Bc analogues. It treats people that are receiving methotrexate by protecting healthy cells from the consequences of methotrexate. Leucovorin injection treats anaemia by supplying vitamin Bc which the red blood corpuscle formation need. It treats colorectal cancer by increasing the consequences of 5-fluorouracil.

Leucovorin injection comes as an answer (liquid) and a powder to be mixed with liquid and injected intravenously (into a vein) or into a muscle. When leucovorin injection is employed to stop harmful effects of methotrexate or to treat an overdose of methotrexate or an identical medication, it’s usually given every 6 hours until laboratory tests show it’s not needed. The experts usually give the Leucovorin injection given once a day, while treating anaemia. When the experts give leucovorin injection to treat colorectal cancer, they usually give it once each day for five days as a part of a treatment; which goes on a repeat once every 4 to 5 weeks.


Doctors utilize Fluorouracil in combination with other medications to treat carcinoma or rectal cancer (cancer that begins within the large intestine); that has got worse or spread to other parts of the body. People use it in combination with other medications; to treat certain types of breast cancer after surgery to remove the tumour or radiation therapy. Fluorouracil is additionally wont to treat cancer of the pancreas and stomach cancer.

Fluorouracil is during a class of medicines called antimetabolites. It works by slowing or stopping the expansion of cancer cells in your body. It additionally sometimes treat cancer of the cervix (opening of the uterus) and esophagus, head and neck cancer (including cancer of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses), ovarian cancer (cancer that begins within the female reproductive organs where eggs are formed), and renal cell cancer (RCC, a kind of cancer that begins in the kidney).

Fluorouracil comes as an answer (liquid) to tend intravenously (into a vein) by a doctor or nurse during a medical facility. The length of treatment depends on the kinds of medicine you’re taking; how well your body responds to them, and therefore the sort of cancer you’ve got. Your doctor may have to delay your treatment or change your dose if you experience certain side effects. It is important for you to inform your doctor how you’re feeling during your treatment with fluorouracil injection.


Irinotecan works alone or together with other medications to treat colon or rectal cancer (cancer that begins within the large intestine). It is a class of antineoplastic medications or topoisomerase I inhibitors. It works by stopping the expansion of cancer cells. Irinotecan comes as a liquid to tend over 90 minutes intravenously (into a vein) by a doctor or nurse. It is usually given less often than once every week, consistent with a schedule that alternates one or more weeks once you receive irinotecan with one or more weeks when you do not receive the medication.

Your doctor will choose the schedule which will work best for you. He/she doctor may offer you medication to stop nausea, vomiting before you receive each dose of irinotecan. Your doctor can also offer you other medication(s) to stop or treat other side effects. Irinotecan is additionally sometimes in use alongside other medications to treat small cell carcinoma. Talk to your doctor about the risks of using this medication for your condition.

Side effects of FOLFIRI Chemotherapy

. Nausea and vomiting

. Risk of Infections

. Mouth Sores

. Anemia