Fluorouracil injection

Fluorouracil injection is to treat:

  • Colorectal cancer
  • Breast cancer
  • Gastric (stomach) cancer
  • Pancreatic cancer

5-FU is another name for fluorouracil. Fluorouracil is also under research for use in the treatment of various diseases and cancers. Fluorouracil can also be used topically.

Definition

Antineoplastic action of the antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine. The modes of action of fluorouracil and its metabolites are diverse. Fluorouracil is transformed in vivo to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP), which replaces uracil in RNA and inhibits RNA processing, halting cell development. Another active metabolite, 5-5-fluoro-2′-deoxyuridine-5′-O-monophosphate (F-dUMP), inhibits thymidylate synthase, depleting thymidine triphosphate (TTP), one of the four nucleotide triphosphates required in vivo DNA synthesis. Other fluorouracil metabolites may be in both RNA and DNA, and their presence in RNA has a significant impact on RNA processing and function.

Fluorouracil Injection – MedlinePlus Information

A summary of key facts regarding this medication in layman’s terms, which may contain the following:

  • Cautions about this medicine
  • What is the use and how?
  • Whom should you consult before taking it?
  • What you should know about it before using it?
  • Other drugs that might interact with it
  • Possible negative effects

Drugs are frequently under research to see whether they can assist treat or prevent conditions other than those already prevalent. This patient information leaflet covers uses which have been under authorization. Much of the material, though, might also apply to authorized uses that are under research.