Use of Etoposide Phosphate in Cancer Treatment

US Brand Name(s): Etopophos

Cancer Use Etoposide phosphate of this formulation:

Experts have authorized Etoposide phosphate for usage in combination with other medications to treat:

Lung cancer with little cells. As a first-line treatment, doctors use it with cisplatin.

Testicular carcinoma is a malignancy of the testicles. In fact, experts use it in individuals who have had surgery, radiation treatment, or other forms of chemotherapy and have not improved.

Etoposide phosphate comes in two forms: etoposide and etoposide phosphate.

Etoposide phosphate is also being researched for use in the treatment of various cancers.


A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent.

Etoposide Phosphate Information from MedlinePlus – A summary of key facts regarding this medication in layman’s terms, which may contain the following:

Cautions about this medicine; what are its uses and how to use it; what you should tell your doctor before taking it; things you should know about it before using it; other drugs that might interact with it; and possible negative effects.

Experts are frequently investigating drugs to see whether they can treat or prevent conditions other than those with authorization. This patient information leaflet only covers authorized uses of the medications. However, much of the material might also apply to authorized uses being investigated.