US Brand Name(s): Doxil
Use in Cancer Treatment
Experts authorize Doxorubicin hydrochloride liposome for its usage alone or in combination with other medicines to treat the following conditions:
AIDS-related Kaposi sarcoma that has progressed following previous forms of systemic chemotherapy, or in individuals who are unable to take other medications.
Multiple myeloma is a kind of cancer that affects the blood cells. Experts give it in combination with bortezomib to patients who have had at least one kind of chemotherapy but have not yet received bortezomib.
Ovarian cancer that has worsened or recurred (came back) following platinum chemotherapy treatment.
Researchers are also investigating the use of doxorubicin hydrochloride liposomes in the treatment of various cancers.
A liposome containing doxorubicin hydrochloride is a kind of doxorubicin hydrochloride (very tiny particles of fat). This type of doxorubicin hydrochloride may function better and have fewer adverse effects than other kinds. It also doesn’t need to be administered as frequently because its effects stay longer in the body. See the Drug Information Summary for Doxorubicin Hydrochloride for further information about doxorubicin hydrochloride that may relate to doxorubicin hydrochloride liposome.
Doxorubicin hydrochloride is a liposome-encapsulated version of the anthracycline antineoplastic drug doxorubicin. Doxorubicin acts by intercalating between base pairs in the DNA helix, blocking DNA replication and, as a result, protein synthesis. Furthermore, doxorubicin inhibits topoisomerase II, resulting in a more stable cleavable enzyme-DNA linked complex during DNA replication and therefore preventing nucleotide strand ligation following double-strand breaking. Doxorubicin also produces oxygen free radicals, which cause cytotoxicity by oxidizing the lipids in cell membranes. Doxorubicin HCL is delivered using liposomes, which increases medication penetration. A liposomal formulation of doxorubicin also reduces toxicity, especially the cardiac effects frequently found with anthracycline anticancer medicines, extending the duration of therapeutic medication effects.
Doxorubicin Hydrochloride Liposome – MedlinePlus Information A summary of key facts regarding this medication in layman’s terms, which may contain the following:
Cautions about this medicine; what are its uses and how to use it; what you should tell your doctor before taking it; things you should know about it before using it; other drugs that might interact with it; and also the possible negative effects
Experts frequently investigate drugs to see whether they can assist treat or prevent conditions other than those for which they have an authorization. This patient information leaflet only covers authorized uses of the medications. However, one may equally apply most of the knowledge to uses which do not have an authorization.