Dactinomycin

US Brand Name(s): Cosmegen

Use in Cancer Treatment

Dactinomycin is for usage alone or in combination with other medications to treat:

  • Adults and children with Ewing sarcoma.
  • Adults and children with gestational trophoblastic illness.
  • Rhabdomyosarcoma is a kind of cancer that affects both adults and children.
  • Recurrent solid tumors on a local level. In adults, it is acts as a palliative and/or adjuvant treatment.
  • Testicular carcinoma is a malignancy of the testicles. It is used in adults and children with metastasized nonseminomas (spread to other parts of the body).
  • Wilms tumor is a kind of cancer that affects both adults and children.

Dactinomycin is also under research for use in the treatment of various cancers.

Antineoplastic chromopeptide antibiotic isolated from Streptomyces parvulus bacteria. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, preventing RNA polymerase from transcribing DNA and causing single-strand DNA breaks, potentially through a free-radical intermediate or an interaction with topoisomerase II.

Dactinomycin Facts on MedlinePlus

A summary of key information regarding this medication in layman’s terms, which may contain the following:

  • Cautions about this medicine
  • What is the use and how?
  • Whom should you consult before taking it?
  • What you should know about it before using it?
  • Other drugs that might interact with it
  • Possible negative effects

Drugs are frequently under research to see whether they can assist treat or prevent conditions other than those already prevalent. This patient information leaflet covers uses which have been under authorization. Much of the material, though, might also apply to authorized uses that are being investigated.