Risk Factors for Childhood Brain stem Glioma

Executive Summary

Risk factors influence the chance of developing cancer among individuals, but individuals with no risk factors also develop Brain stem Glioma cancer. The individual’s risk factors in bone cancer evolve into childhood brainstem glioma due to several risk factors such as genetic conditions associated with a higher risk of developing a CNS tumor. Other risk factors include Neurofibromatosis type 1 (NF1), Li-Fraumeni syndrome, Turcot syndrome, Nevoid basal cell carcinoma, and Tuberous sclerosis complex (TSC).

Risk Associated with Brain stem Glioma – Childhood

The Risk Factors for Brain stem Gliomas can be anything that influences the chance of developing any cancer. But having a risk factor, or many does not give certainty of having particular cancer. Some people with no risk factors can also develop cancer

Doctors and researchers do not know what causes most childhood tumors, including brain stem gliomas. There is little evidence that genetic factors may play a role in a small percentage of brain stem gliomas.

The genetic conditions are associated with a higher risk of developing a CNS tumor (Central Nervous System tumor) ​1​. Still they are not explicitly related to developing a brain stem glioma:

  • Neurofibromatosis type 1 (NF1)
  • Li- Fraumeni syndrome
  • Turcot syndrome
  • Nevoid basal cell carcinoma
  • Tuberous sclerosis complex (TSC)

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References for Brain stem Glioma
  1. 1.
    Ostrom QT, Fahmideh MA, Cote DJ, et al. Risk factors for childhood and adult primary brain tumors. Neuro-Oncology. Published online July 12, 2019:1357-1375. doi:10.1093/neuonc/noz123