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Finding The Best Donors For Bone Marrow Transplant

Finding The Best Donors For Bone Marrow Transplant

A bone marrow transplant (BMT) is a process performed to replace either the destroyed or damaged bone marrow with healthy bone marrow. Bone marrow is soft and fatty tissue present inside the bone, producing blood cells.

BMT usually involves taking the cells found in the bone marrow and then giving them back to the patient or another person. BMT aims to transfuse the healthy bone marrow cells into a person after his unhealthy bone marrow has been treated for killing the abnormal cells. Bone marrow is present in your large bones. It produces around   200 billion new blood cells every day, including white blood cells, red blood cells and platelets. But it does not work correctly for people with bone marrow disease, including several types of cancer. A bone marrow transplant increases a person’s chance of survival, and it is the best cure—a bone marrow transplant exchanges unhealthy bone marrow with healthy tissue.

Why does one require a Bone Marrow Transplant?

 A bone marrow transplant is an essential treatment for some people with a blood cancer like lymphoma, myeloma and leukaemia. After a blood transplant, you can take high doses of chemotherapy and other treatments. Doctors take stem cells are from the bloodstream or the bone marrow. People have a transplant either using their stem cells (autologous transplant) or stem cells from a matching donor (allogeneic transplant). Different types of diseases may affect the functioning of the bone marrow and may require bone marrow transplants. Some similar conditions are:

Multiple Myeloma

Multiple Myeloma treatment happens with the help of bone marrow transplant. It is a cancer that develops in the white blood cell. A bone marrow transplant can be a practical part of treating multiple Myeloma. Hematopoietic stem cells are located in the bone marrow. They can produce blood cells, such as white blood cells, red blood cells, and platelets. In this procedure, the experts collect the hematopoietic stem cells from the patient or another person.

Amyloidosis

Amyloidosis is a rare disease. It occurs when amyloid (an abnormal protein, usually formed in the bone marrow) is dumped in any tissue or organ, and it starts interfering with its normal functions. Depending upon the type of amyloidosis, a bone marrow transplant may be recommended.

Acute or chronic Leukemia

It is a blood or bone marrow cancer that may eventually need a bone marrow transplant in specific high-risk subtypes.

Hodgkin’s or Non-Hodgkin’s Lymphoma

Hodgkin’s or Non-Hodgkin’s Lymphoma are the cancer of lymphocytes (type of white blood cell). These lymphocytes are a significant factor for the immune system.

Myelofibrosis

Myelofibrosis is the rarest type of blood cancer where bone marrow is replaced by fibrous scar tissue. Bone marrow transplant is a treatment that might benefit this medical condition.  

Germ cell tumors

These are tumors where there is the growth of cells from reproductive cells. They may be cancerous or non-cancerous and are mainly found in the ovaries or the testicles.

Immune disorders

These disorders can lead to abnormally low activity or overactivity of the immune system. Overactivity of the immune system causes the body to attack and damage its tissues (autoimmune diseases). Low immune system activity decreases the body’s stamina to fight outsiders, making it vulnerable to infections.

Bone marrow failure

Bone marrow cannot form blood cells. After receiving chemotherapy and radiation therapy for cancer, some patients may need a bone marrow transplant for Aplastic Anaemia or Myelodysplastic syndrome. Some patients after receiving chemotherapy and radiation therapy for cancer, may need a bone marrow transplant.

How to find matching donor cells

To be a donor, your stem cell must be matches with the stem cells of the person you are donating. To confirm this, doctors do a blood test. This blood test looks at HLA typing or tissue typing. Bone marrow transplantation is a difficult medical procedure and doctors do not recommend it for everyone. The healthcare team would evaluate the patient by conducting various medical tests, a complete physical examination and psychosocial evaluations to decide whether that patient is a suitable candidate for bone marrow transplantation.

Conditions required for donating cells

You could become a healthy donor for a bone marrow transplantation if you meet the following conditions:

Age: Healthy individuals between 18 to 60 years could be ideal candidates for a bone marrow transplantation.

Weight: To register as a potential blood stem cell donor, the maximum Body-Mass-Index (BMI) limit is 40 kg/m2. Additionally, if a person is not eligible for donating their blood stem if his weight is below 50 kg.

Health conditions: People with autoimmune diseases, chronic illnesses, such as diabetes or rheumatism, chronic heart diseases, chronic lung diseases, infectious diseases, such as HIV, hepatitis B or hepatitis C, and syphilis cannot be a donor. Blood disorders are not eligible for donating their stem cells. If someone is suffering from the central nervous system or any mental illness, he is not suitable for a blood transplant. 

Pregnant women can also donate blood stem cells. But they cannot donate until they fully recover after the delivery—types of transplantation. 

There are three different types of bone marrow transplants. 

Autologous bone marrow transplant

This is a bone marrow transplant where your cells are in use. Before receiving a high dose of radiation or chemotherapy, a doctor removes your cells and stores them in the freezer in this treatment. After receiving radiation or chemotherapy treatments, these cells are put back in your body to help in making normal blood cells. This is also a rescue transplant.

Allogeneic bone marrow transplant

This is a type of bone marrow transplant where the doctors remove cells from another person (donor). Most times, the genes of the donor must at least partly match your genes. Before initiating the process, doctors do some special tests to see if a donor is a good match for you. A sibling is most likely to be a good match. However, sometimes children, parents, and other relatives are also suitable matches. In some cases, the doctors consider those donors who are not related to you but matches you.

Umbilical cord blood transplant

This transplant is a type of allogeneic transplant. In this process, the doctors remove the cells from a new born baby’s umbilical cord right after birth. They freeze these cells and store until they are in need for a transplant in the future. Umbilical cord blood cells are quite immature, so there is less of a need for perfect matching. Due to the lesser number of cells, blood counts may take much longer to recover.

Types of bone marrow transplantation donors

Optimal donors: These donors have an identical HLA tissue typing, and are mostly a relative of the recipient, usually a sibling or, in rare cases, a parent or grandparent.

Partially matched donors: These donors have a 50% HLA tissue match (always half matched, or haplo compatible) with the recipient. Biologic parents are always partially matched donors for the recipient.

Alternative donors: These donors are unrelated to the recipient. They are healthy individuals with matching HLA tissue typing with the patient and are willing to donate bone marrow stem cells.

Autologous donors:  In this type, the recipients themselves are the donors. Here the stem cells that circulate in the bloodstream are collected and are frozen or stored for later use. The recipient can donate only when his or her body produces enough healthy bone marrow cells.

Donating stem cells or bone marrow to a relative

A brother or sister is most likely to be a match for bone marrow transplant. There is a 1 in 4 chance of your cells matching. This is a matched related donor (MRD) transplant. Anyone else in the family is unlikely to match. This can be very frustrating for relatives who are keen to help.

Sometimes if your cells are a half (50%) match, you might still be able to donate stem cells or bone marrow to a relative. This is a haploidentical transplant.

You can’t donate stem cells or bone marrow to your relative if you’re not a match.

It is sometimes possible to get a match from someone outside of the family. This is a matched unrelated donor. To find a matched unrelated donor, it is usually necessary to search large numbers of people whose tissue type has been tested. So, doctors search national and international registers to try to find a match for your relative.

Even if you can’t donate to your relative, you might be able to become a donor for someone else.

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