Sign and Symptoms for B-cell Prolymphocytic and Hairy Cell Leukemia

People having HCL or PLL may experience the following signs or symptoms. Sometimes, people with HCL or PLL don’t have these symptoms. Or, the cause of a symptom can be a different medical condition that is not Leukemia.

  • Bruising easily
  • In HCL, hairy cells accumulate more often in the bone marrow and spleen and may not cause noticeable lymph node swelling. Enlarged lymph nodes in PLL. 
  • Unexplained fatigue
  • Slow wound healing
  • Decreased appetite and feeling full quickly
  • Persistent abdominal pain on the left side from an enlarged spleen
  • Unexplained weight loss
  • Frequent infections
  • Chills
  • Fever
  • Night sweats