Signs and Symptoms of Acute Lymphocytic Leukemia

Executive Summary

Acute lymphocytic leukemia is diagnosed based on its symptoms. And so, the signs and symptoms of the lymphocytes experienced by the individuals help describe the current condition. The most common symptoms of acute lymphocytic leukemia include fever, easy bruising, fatigue, red, pinhead-sized spots on the skin, weakness, pale skin, bone, back or abdominal pain, swollen lymph nodes also called glands, nausea and vomiting, difficulty breathing or shortness of breath, frequent infections or infections that come back, headache, blurred vision, enlarged liver or spleen, and dizziness.

Signs and Symptoms of Acute Lymphocytic Leukemia

People with Acute Lymphocytic Leukemia may experience the following signs or symptoms ​1​. Even so, children with ALL do not have any of these changes. Or, the cause of a symptom can be a different medical condition that is not cancer.

  • Fever
  • Easy bruising
  • Fatigue
  • Red, pinhead-sized spots on the skin
  • Weakness
  • Pale skin
  • Bone, back or abdominal pain
  • Weight loss
  • Swollen lymph nodes also called glands
  • Nausea and vomiting
  • Difficulty breathing or shortness of breath
  • Frequent infections or infections that come back
  • Headache
  • Blurred vision
  • Enlarged liver or spleen
  • Dizziness


  1. 1.
    Alvarnas JC, Brown PA, Aoun P, et al. Acute Lymphoblastic Leukemia, Version 2.2015. J Natl Compr Canc Netw. Published online October 2015:1240-1279. doi:10.6004/jnccn.2015.0153